ABSTRACT
Purpose>In the current urban and increasingly digital/information era, the service of property management towards residents is of key importance to the well-being of society, which is especially well reflected in its role during the COVID-19 pandemic in China. However, professional knowledge management (KM) has yet to be applied to the daily operation of the property management companies in this sector. The authors posit that introduction of KM concepts to property management at this time would significantly help facilitate the transition of traditional property management towards a higher and more effective value-added service model. From the perspective of KM, this study aims to offer both a theoretical and practical analysis of such a novel business model for companies in the property management industry.Design/methodology/approach>Given the current status quo of property management, the authors integrate theories from both KM and information-digital management to qualitatively analyse the challenges and difficulties companies are facing and importantly offer practical suggestions for the centralization, digital-information platform establishment and service innovation.Findings>Following the analysis of KM and digital-information modeling, the authors identify three main challenges facing property management services offered in the current digital society including market fragmentation, lack of digital platforms and the absence of a unitary service model. Therefore, the authors propose strategic solutions to resolve these aforementioned problems. Specifically, the authors suggest centralizing property management service, the establishment of a KM-based digital platform and the upgrading of the service model, towards offering a new impetus for the development of companies in property management.Research limitations/implications>The authors offer essential guidelines derived from knowledge and information management and explore their implications both from a theoretical, as well as pragmatic/practical perspective that overall would support property management companies’ crucial transition from the traditional service model to a more digital-based foundation, and hence, provide a higher value-added service for the residents.Originality/value>The current study is one of the first attempts to analyse property management services from the perspective of KM with digital transformation enabling its transition to an information-based internet of things infrastructure. The study not only offers practical guidance to the business of property management but importantly, also contributes to the theoretical underpinnings of KM especially as related to secure serviceability, well-being, security and efficiency of the residential environment by integrating people, place, process and technology.
ABSTRACT
Immune checkpoints (ICPs) consist of paired receptor-ligand molecules that exert inhibitory or stimulatory effects on immune defense, surveillance, regulation, and self-tolerance. ICPs exist in both membrane and soluble forms in vivo and in vitro . Imbalances between inhibitory and stimulatory membrane-bound ICPs (mICPs) in malignant cells and immune cells in the tumor immune microenvironment (TIME) have been well documented. Blockades of inhibitory mICPs have emerged as an immense breakthrough in cancer therapeutics. However, the origin, structure, production regulation, and biological significance of soluble ICPs (sICPs) in health and disease largely remains elusive. Soluble ICPs can be generated through either alternative mRNA splicing and secretion or protease-mediated shedding from mICPs. Since sICPs are found in the bloodstream, they likely form a circulating immune regulatory system. In fact, there is increasing evidence that sICPs exhibit biological functions including (1) regulation of antibacterial immunity, (2) interaction with their mICP compartments to positively or negatively regulate immune responses, and (3) competition with their mICP compartments for binding to the ICP blocking antibodies, thereby reducing the efficacy of ICP blockade therapies. Here, we summarize current data of sICPs in cancer and infectious diseases. We particularly focus on sICPs in COVID-19 and HIV infection as they are the two ongoing global pandemics and have created the world’s most serious public health challenges. A “storm” of sICPs occurs in the peripheral circulation of COVID-19 patients and is associated with the severity of COVID-19. Similarly, sICPs are highly dysregulated in people living with HIV (PLHIV) and some sICPs remain dysregulated in PLHIV on antiretroviral therapy (ART), indicating these sICPs may serve as biomarkers of incomplete immune reconstitution in PLHIV on ART. We reveal that HIV infection in the setting of alcohol abuse exacerbates sICP dysregulation as PLHIV with heavy alcohol consumption have significantly elevated plasma levels of many sICPs. Thus, both stimulatory and inhibitory sICPs are present in the bloodstream of healthy people and their balance can be disrupted under pathophysiological conditions such as cancer, COVID-19, HIV infection, and alcohol abuse. There is an urgent need to study the role of sICPs in immune regulation in health and disease.